With the Gyaos re-emerging, Gamera's ties to humanity have been severed with his bond to Asagi broken. Nagamine and Asagi investigate while an orphaned girl named Ayana discovers a new creature she names Iris. Nagamine and Asagi must reach Ayana before she takes her revenge on Gamera, who she blames for the death of her family.
Starring Ai Maeda, Shinobu Nakayama, Aki Maeda, Ayako Fujitani, Yû Koyama, Nozomi Ando, Ito Takahiro, Senri Yamazaki, Toru Tezuka, Yukijiro Hotaru